Welcome
Dear friends and colleagues,
While the existence of membrane-less organelles, such as nucleoli, stress granules or Cajal bodies has been known for a long time, it has remained largely unclear how such organelles are actually formed, maintained and regulated. We now know that compartments can also be formed by the phase separation of proteins, RNA and DNA and combinations thereof.
To investigate the newly emerging role of phase separation in biology, we need to develop new tools and approaches, as well as combine cell biology and biophysics with biochemical reconstitution, theory and modelling.
This meeting will bring together scientists from different disciplines which will synergistically decipher how novel functions and pathologies emerge from the process of phase separation in biological systems, and what molecular underpinnings facilitate and regulate this key process.
We are looking forward to an exciting meeting and cordially invite you to participate!
The meeting of the priority program 2191 on the Molecular Mechanism of Functional Phase separation will precede the GBM compact with the aim to extend this 1.5-day meeting by another 1.5-day meeting. It will bring additional talks and poster sessions from members of the priority program and a keynote talk by Rohit Pappu. We would be excited to additionally welcome you to this event.
Simon Alberti / Sara Cuylen-Haering / Dorothee Dormann / Edward Lemke / Julia Mahamid / Claus Seidel / Konstanze Winklhofer
Program
-
Alexander Büll -
Nagarja Chappidi -
Herman Fung -
Amy Gladfelter -
Lars Hubatsch -
Anthony Hyman -
Janine Kirstein -
Christine Mayr -
Tanja Mittag -
Sua Myong -
Michael Rosen -
Benjamin Sabari -
Daxiao Sun
The SPP2191: Molecular Mechanisms of Functional Phase Separation will be hosting a satellite meeting which aims to extend the GBM Compact by a 1.5-day meeting. It will bring additional talks and poster sessions from members of the priority program as well as a keynote talk by Rohit Pappu from Washington University in St. Louis.
Dates: September 16-17, 2025
Start Times: 12:00 September 16, 9:00 September 17
Lunch, dinner, and coffee breaks will be provided on both days
Location: Leonardo Royal Hotel Frankfurt (Mailänder Straße 1, Frankfurt am Main, Germany)
| 13:00 - 13:15 (HS22-01) |
Opening remarks |
| 13:15 - 14:15 (HS22-01) |
Fritz Lipmann Lecture: Michael Rosen (Dallas,USA) Multi-Scale Structure of Chromatin Condensates |
| 14:15 - 14:45 (HS22-01) |
Amy Gladfelter (Durham, USA) How a physical code in RNA organizes the cytoplasm |
| 14:45- 15:00 (HS22-01) |
Short talk 1 to be selected from the submitted abstracts |
| 15:00 - 15:45 | Coffee break |
| 15:45 - 16:15 (HS22-01) |
Benjamin Sabari (Dallas, USA) RNA Polymerase II partitioning is a shared feature of diverse oncofusion condensates |
| 16:15 - 16:45 (HS22-01) |
Alexander Büll (Copenhagen, DK) Large scale exploration by mRNA display of the interactions driving condensate formation of intrinsically disordered proteins |
| 16:45- 17:00 (HS22-01) |
Short talk 2 to be selected from the submitted abstracts |
| 17:00 - 17:15 (HS22-01) |
Short talk 3 to be selected from the submitted abstracts |
| 17:15 - 17:30 (HS22-01) |
Short talk 4 to be selected from the submitted abstracts |
| 17:30 - 18:00 | Break |
| 18:00 - 18:30 (HS22-01) |
Poster teasers to be selected from the submitted abstracts |
| 18:30 - 21:00 | Poster session & Get together |
| 09:00 - 09:30 (HS22-01) |
Janine Kirstein (Jena, DE) Hsc70, DNAJB1 and Apg2 regulate HTT from the soluble state to condensates to amyloid fibrils and in reverse |
| 09:30 - 10:00 (HS22-01) |
Sua Myong (Boston, USA) FUS granule assembly mechanism |
| 10:00 - 10:15 (HS22-01) |
Short talk 5 to be selected from the submitted abstracts |
| 10:15 - 10:50 | Coffee break |
| 10:50 - 11:10 (HS22-01) |
Independent Accelerator Session: Lars Hubatsch (Dresden, DE) Transport Kinetics across Phase Boundaries |
| 11:10 - 11:30 (HS22-01) |
Independent Accelerator Session: Nagarja Chappidi (Dresden, DE) Molecular Safeguards of Genome Stability |
| 11:30 - 11:50 (HS22-01) |
Independent Accelerator Session: Herman Fung (Ann Arbor, USA) Genetically encoded tags for localizing bimolecular condensates in cellular cryo-electron tomography |
| 11:50- 12:10 (HS22-01) |
Independent Accelerator Session: Daxiao Sun (Dresden, DE) Building barriers: the power of surface condensation in epithelial sealing |
| 12:10 - 13:30 | Lunch break |
| 13:30- 14:00 (HS22-01) |
Christine Mayr (New York, USA) How the location of protein synthesis controls protein activity in the nucleus |
| 14:00 - 14:30 (HS22-01) |
Tanja Mittag (Memphis, USA) Title to be announced |
| 14:30 - 15:00 (HS22-01) |
Tony Hyman (Dresden, DE) Phase separation in cell physiology and disease |
| 15:00 | Poster prizes & Closing remarks |
Registration
Important Dates
Start registration: May 7
Deadlines:
Early registration: June 30
Regular registration: August 31
Start late registration: September 1
On site registration is possible.
Abstract submission: June 30
Registration Fees
| Non-members* | early | regular | late |
| Regular | 250 | 280 | 310 |
| Student/ Retiree |
120 | 145 | 170 |
All prices in EURO
| Members* | early | regular | late |
| Regular | 200 | 225 | 250 |
| Student/ Retiree |
100 | 125 | 150 |
All prices in EURO
If you want to join the GBM with your registration to enjoy the reduced participation fee, please fill in the online membership application.
* member of the GBM, DECHEMA, DGZ, GDCh, VAAM, Bunsen Society
(Please bring a proof of your membership to the Kolloquium.)
We thank for the kind support by:
Information
Accommodation
We do not have an overview of the current vacancies of the hotels in and around Frankfurt. We therefore recommend booking via online portals such as booking.com or hotel.de.
Abstracts
Please submit your abstract online after you finished the registration process.
All neccessary information will be provide during the abstract submission process.
In case you are preparing your abstract offline please mind the maximum length of 1500 characters.
Conference Proceedings
Your name badge will be available at the registration desk in Frankfurt. Please wear your name badge during the whole meeting.
We do not provide a program and abstract book. Please download the pdf shortly before the meeting or use the online list of abstracts in the program booklet
Grants
As a young member of the GBM you can apply for a travel grant until July 15.
Still not a member of the GBM? Here you can apply for it.
Internet
A wireless LAN connection is available.
Name: ukfguest
Password: ukfguest
(activated for three days after registration)
Meals & Drinks
Coffee, tea and mineral water will be provided for free during the coffee breaks.
A fingerfood lunch on Friday lunchtime is also included in the registration fee.
Lunch and Dinner on Thursday is available at your own expense nearby the conference building:
Cafeteria in house 20 (opposite the venue, open from 8 a.m. to 4 p.m.), Mensa in house 35 (see campus map).
Office
Numbers of the conference office (during the opening hours): +49 69 660567 0
Opening hours:
| Tuesday | 12:00 - 18:00 |
| Wednesday | 08:30 - 15:30 |
Posters
Poster contributions can be submitted on the registration page after you have registered for participation in the conference.
The poster should be prepared in portrait format (DIN A0 resp. ~120 x 85 cm). Please present your poster throughout the whole meeting.
We provide material for mounting the posters.
The best two posters will receive a GBM poster prize with 300 € prize money each at the end of the meeting.
Five short talks will be selected from the submitted poster abstracts.
Visa
As a participant from abroad you may need a visa from the German embassy. If so please contact the meeting secretariat. We will send you the required invitation letter.
Organization & Contact
Scientific Organisation
Simon Alberti
Technische Universität Dresden
Sara Cuylen-Haering
EMBL Heidelberg
Dorothee Dormann
Johannes Gutenberg-Universität Mainz
Edward Lemke
Johannes Gutenberg-Universität Mainz
Julia Mahamid
EMBL Heidelberg
Claus Seidel
Heinrich Heine Universität
Konstanze Winklhofer
Ruhr University
