Abstracts
In situ structural analysis of the nuclear pore complex
Martin Beck
Frankfurt am Main, Germany
Nuclear pore complexes mediate nucleocytoplasmic exchange. We have previously shown that mechanical forces acting on the nuclear envelope induce changes in nuclear pore complex diameter and interplay with the nuclear transport system. I will discuss our more recent work that visualizes such dynamic changes during stem cell differentiation and viral infection based on advanced imaging techniques such as cryo electron tomography and subtomogram averaging.