Microscopy-based systematic approaches to identify new players in lipid droplet biology

Maria Bohnert

Münster, Germany

Lipid droplets (LDs) are ubiquitous organelles that fulfil central roles in lipid storage and metabolism. LD dysfunction is related to human diseases including lipodystrophy, obesity, diabetes, fatty liver, and cardiovascular diseases. Despite their (patho-)physiological relevance, key LD biology processes including organelle formation, degradation, motility, protein targeting, and communication with the rest of the cell are incompletely understood. My lab uses microscopy-based genome-wide screening approaches in the yeast Saccharomyces cerevisiae to identify unknown players in organelle biology. We identify molecular mechanisms underlying the life cycle of the LD.

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